IBAS - What we do - Publications

Sensory detection of threshold intensity resistive loads in severe obstructive sleep apnoea

Authors	Ruehland, WR. Rochford, PD. Pierce, RJ. Webster, KE. Trinder, JA. Jordan, AS. O'Donoghue, FJ.
Type	Accepted for Publication
Journal	Respiratory Physiology & Neurobiology
Year of Publication	2016
URL	http://www.sciencedirect.com/science/article/pii/S1569904816302488
DOI	http://dx.doi.org/10.1016/j.resp.2016.10.014
Abstract	Respiratory related evoked potentials (RREPs) were used to investigate whether sensory detection of small mid-inspiratory resistive loads (≈1.2 to 6.2 cmH2O·L‐1·s), delivered during wakefulness, was impaired in obstructive sleep apnoea (OSA). It was reasoned that impaired detection of minor airway patency challenge may lead to difficult-to-remedy further collapse. There was a significant reduction in OSA (n = 16) vs. control (n = 17) participants in the slope of the relationship between the P1 RREP component amplitude, which reflects arrival of somatosensory information at the cortex, and stimulus intensity, expressed as change in epiglottic pressure (mean [95% confidence intervals]: ‐0.50 [-0.97, −0.03] vs. −1.78 [-2.54, −1.02]; P = 0.004), suggesting a reduction in sensitivity to small respiratory loads. However there was no significant difference in sensitivity after background Pepi was taken into account (P = 0.268). Additionally, there were no significant group differences in the threshold of the P1 amplitude/stimulus intensity relationship, or in the P1 latency. These results indicate a reduced sensitivity to detection of small upper airway negative pressure stimuli in OSA related to a reduction in mechanoreceptor activation (likely related to increased airway resistance in OSA vs. controls; P = 0.002) rather than defective mechanosensory function.

Authors

Ruehland, WR.
Rochford, PD.
Pierce, RJ.
Webster, KE.
Trinder, JA.
Jordan, AS.
O'Donoghue, FJ.

Type

Accepted for Publication

Journal

Respiratory Physiology & Neurobiology

Year of Publication

2016

URL

http://www.sciencedirect.com/science/article/pii/S1569904816302488

DOI

http://dx.doi.org/10.1016/j.resp.2016.10.014

Abstract

Respiratory related evoked potentials (RREPs) were used to investigate whether sensory detection of small mid-inspiratory resistive loads (≈1.2 to 6.2 cmH2O·L‐1·s), delivered during wakefulness, was impaired in obstructive sleep apnoea (OSA). It was reasoned that impaired detection of minor airway patency challenge may lead to difficult-to-remedy further collapse. There was a significant reduction in OSA (n = 16) vs. control (n = 17) participants in the slope of the relationship between the P1 RREP component amplitude, which reflects arrival of somatosensory information at the cortex, and stimulus intensity, expressed as change in epiglottic pressure (mean [95% confidence intervals]: ‐0.50 [-0.97, −0.03] vs. −1.78 [-2.54, −1.02]; P = 0.004), suggesting a reduction in sensitivity to small respiratory loads. However there was no significant difference in sensitivity after background Pepi was taken into account (P = 0.268). Additionally, there were no significant group differences in the threshold of the P1 amplitude/stimulus intensity relationship, or in the P1 latency. These results indicate a reduced sensitivity to detection of small upper airway negative pressure stimuli in OSA related to a reduction in mechanoreceptor activation (likely related to increased airway resistance in OSA vs. controls; P = 0.002) rather than defective mechanosensory function.

http://www.ibas.org.au/what-we-do/publications/3872878

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Sensory detection of threshold intensity resistive loads in severe obstructive sleep apnoea